The quite simple answer to this query is yes, methylfolate improves your mood. It doesn’t mean that you may think methylfolate itself happiness chemical; please clear yourself it involves the pathway that produces happiness chemicals.

What is Methylfolate?

Methylfolate is a functional form of vitamin B9 or folates that produce naturally inside your body, available synthetically as well. Your body is gifted with the MTHFR enzyme that converts folates or folic acid into methylfolate inside the body. It helps your body grow successfully by inducing cell division (formation of new cells) and driving various mechanisms. Methylfolate with vitamin B12 controls many significant body mechanisms.

The novel characteristic of methylfolate is to pass through the blood-brain barrier and modulate your brain activities.

You may know methylfolate is the sole chemical prescribed as a medicinal food because of its minimum side effects compared to other medicines. You may evaluate that its deficiency produces many health problems. The USA government advised the food manufacturers to add folic acid, methylfolate, and other forms of folate in fortified food and dietary supplements.

How does methylfolate improve mood?

No doubt, methylfolate is a blessing chemical and helps to improve your mood. The mood is your internal state, whether you are happy or not, and relates to your emotions. While your mental condition or mood is not stable, your brain abilities are affected, and you also experience stress in your whole body. It’s not easy to live happily in this competitive world and it offers various challenges and adventures.

Don’t worry; methylfolate may help you come out of the box of stress, depression, sadness, and anxiety. However, let’s close inspection how does methylfolate improves your mood.

Production of happiness chemicals:

The chemicals responsible for your happiness are produced from your brain with the aid of methylfolate. It helps the formation of tetrahydrobiopterin (BH4), the main and most crucial cofactor in synthesizing serotonin, dopamine, and norepinephrine, also known as neurotransmitters. These mood-swinging chemicals modulate your mood. If you have a high level of happiness chemicals, you may feel happy and enjoy yourself and vice versa.

Therefore, the psychiatrist prescribed a methylfolate dose with anti-depressant drugs to enhance their efficiency as adjunctive therapy in curing depression disorders.

In this way, methylfolate helps to improve or stable your mood.

Methylfolate and Pregnancy:

Methylfolate is the most demanding chemical during pregnancy; it optimizes naive babies’ proper growth and development. A methylfolate dose of more than 500 mcg/day is recommended to pregnant women. It lowers the symptoms of depression and stabilizes the mood of the mother.

Methylfolate and MTHFR gene mutation:

Methylfolate is vital for patients with MTHFR gene mutation; their body cannot produce the MTHFR enzyme that is required for the transformation of folate into methylfolate. Consequently, they adopt various diseases due to the deficiency of methylfolate. Luckily, methylfolate is prepared synthetically, and the affected person can intake methylfolate supplements to drive their lives. Before you starting taking vitamin B12 for MTHFR gene defects you should know that there are best forms of B12 for MTHFR available at your supplement shop. You should talk to your doctor to find out what is the best form of B12 for your MTHFR gene defect.


Methylfolate is a valuable chemical synthesized naturally inside the body and synthetically also available thanks to scientists. Its presence is indispensable for producing mood-regulating chemicals that make your mood good. Its low level may induce depressive symptoms because its inadequate amount produces fewer happiness chemicals; you may feel bad. Therefore, its deficiency is replenished by taking folate-rich food and methylfolate supplements.


Read more about this website:


Comments are closed.